| Brand Name (Date of FDA Approval) | What It Treats | Key Active Ingredient | Length of Effectivenes | Some Possible Side Effects |
| Dysport (2009) | Frown (glabellar) lines. Off-label: other dynamic facial wrinkles | Botulinum toxin type A | 3-6 months (perhaps longer) | Bruising and numbness at injection site; headache; nose and throat irritation; in rare cases, droopy eyelids |
| Botox (2002) | Frown (glabellar) lines and excessive sweating (hyperhidrosis). Off-label: other dynamic facial wrinkles | Botulinum toxin type A | 3-6 months for wrinkles; up to 1 year for hyperhidrosis | Bruising, redness, and numbness at injection site; nausea and headache; in rare cases, droopy eyelids |
| Zyderm & Zyplast (1981 & 1985) | Frown (glabellar) lines; nasolabial folds; acne scars; other soft tissue defects. (Zyderm is used for superficial lines, while Zyplast is used for deeper wrinkles.) Off-label: non-facial areas | Purified bovine-derived (cow) collagen | Zyderm: 2-5 months; Zyplast: 9-12 months | Tenderness, redness, swelling and bruising at injection site |
| Cosmoderm & Cosmoplast (2003) | Fine lines, wrinkles, and scars. (Cosmoderm is used for superficial lines, while Cosmoplast is used for deeper wrinkles.) Off-label: non-facial areas | Purified human collagen | 2 - 3 months | Swelling and redness at injection site; in rare cases, small temporary bumps may form under skin |
| Autologous Fat Fillers (doesn't require FDA approval) | Deep wrinkles; lost volume to cheeks, lips and other facial areas (as well as to the back of hands) | Patient's own fat (removed from buttocks, abdomen, or thighs) | 3-12 months | Tenderness, redness, and swelling at treated area and at area from which fat is removed |
| Radiesse (2006) | Nasolabial folds. Off-label: other facial wrinkles, folds, and depressions | Calcium hydroxylapatatite (CaHA) particles suspended in a carboxymethyl-cellulose gel | About 1 year | Swelling and bruising at injection site |
| Restylane (2003) | Lines around the mouth and lips. Off-label: Lines around the eyes and elsewhere on the face; adding volume to lips, cheeks and other facial areas | Hyaluronic acid | Facial lines: 6-9 months; fuller lips: 3- 6 months | Swelling, redness, and bruising at injection site; in rare cases, small temporary bumps may form under skin |
| Juvederm Ultra & Juvederm Ultra Plus (2001 & 2007) | Moderate to deep wrinkles and creases around mouth | Hyaluronic acid | 4 -9 months | Tenderness, swelling, bruising, redness, and itching around the injection site; in rare cases, small temporary bumps may form under skin |
| Sculptra (2009 for cosmetic purposes; 2004 for lipoatrophy) | Nasolabial folds and other deep facial wrinkles; facial fat loss(lipoatrophy), including "hollow" cheeks, in people living with HIV/AIDS | Poly-L-lactic acid | Up to 2 years | Swelling, redness, and bruising at injection site; in rare cases, small temporary bumps may form under skin |
| Perlane (2007) | Nasolabial folds and other moderate to severe facial wrinkles | Hyaluronic acid | 3-6 months | Swelling and redness at injection site; in rare cases, small temporary bumps may form under skin |